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The patient demographic predominantly consisted of individuals aged between 18 and 64 years, accounting for 53.57%77.42% of the sample, while the proportion of minors ranged from 8.57% to 21.34%

Copper absorption primarily occurs in the duodenum, where dietary Cu2+ is reduced to Cu+ by metalloreductases such as six-transmembrane epithelial antigen of the prostate 4 and duodenal cytochrome B (26,27)

This bioavailability bottleneck has practical consequences for the interaction discussion

Some people may have poor B12 absorption due to genetics and therefore need an individual B12 intake plan to maintain healthy levels (Temova Rakua et al., 2022)

Nevertheless, it is important to exercise caution, as research conducted by Bortolotti et al