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Abbreviations ASCVD: Atherosclerotic cardiovascular disease ACLY: ATP citrate lyase APOA1: Apolipoprotein A-I CDK5 activator: Cyclin-dependent kinase 5 activator CYP: Cytochrome P450 DFT: Density functional theory DILI: Drug-induced liver injury ESP: Electrostatic potential EVOO: Extra virgin olive oil FA: Fatty acids GC-FID: Gas chromatography flame ionization detector hERG: Human ether-a-go-go-related gene HIA: Human intestinal absorption HIF1A: Hypoxia-inducible factor 1-alpha HOMO: Highest occupied molecular orbital LDL-C: Low-density lipoprotein cholesterol LDLR: LDL receptor LUMO: lowest unoccupied molecular orbital MUFA: Monounsaturated fatty acid PASS: Prediction of activity spectra for substances PC: Phenolic compounds PCSK9: Proprotein convertase subtilisin/kexin type 9 SPME: Solid-phase microextraction SMILES: Simplified molecular line entry system TPC: Total phenolic content VC: Volatile organic compounds References Galan, P., & Hercberg, S

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Lateral Tracking Forces : Abnormal tracking of the patella: laterally, or higher (patella alta) can cause abnormal loading, and risk instability Chondromalacia and the soft tissue structures of the knee Hoffas Fat Pad: Inflammation or impingement Chondral Surfaces: injury to the cartilage Synovium: Inflammation of swelling Patella and Trochlea Groove: Bone marrow oedema

10.1177/1099800414544949 76 GruberB