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Furthermore, TGF- is implicated in various pathological processes associated with PH, including cell proliferation, apoptosis, metabolic dysregulation, mitochondrial dysfunction, inflammation, immunomodulation, ECM remodeling, fibrosis, and EndMT (Fig

Due to the high sequence similarity among Ube2e1, Ube2e2, and Ube2e3, we modeled this region based on the Ube2e2 sequence but removed the side chains (Supplementary Fig