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Description

Serotonergic effects contribute to both mood stability and cognitive flexibility

2010;16:BR81BR88

In the ischemia/reperfusion-induced fibrosis C57BL/6J mouse model, transcriptomic and metabolomic analyses showed that dapagliflozin treatment mitigated accumulation of tricarboxylic acid (TCA) circulating metabolites and up-regulation of inflammation in fibrotic renal cortical tissue

In the HD model, reduced expression and deacetylase activity of SIRT3, which in turn prevents the deacetylation of LKB1 and SOD2, leading to a decrease in the level of NAD + , defects in mitochondrial biogenesis and accumulation of ROS

Cyclic AMP response element (CRE)-reporter assay A BHK cell line was stably transfected with the human calcitonin (a) receptor (hCTR a ) and a cAMP responsive element (CRE) luciferase reporter gene