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Overall, anti-IL-12/23 and anti-IL-23 agents provide an effective new option for moderate-to-severe IBD in patients who fail or are intolerant to anti-TNF therapy, and future generations of anti-IL drugs targeting finer subunits or downstream signaling will further promote precision and personalized treatment

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Impaired insulin signaling in diabetic patients results in insufficient hepcidin synthesis, increased intestine iron apparent absorption, and elevated circulating iron level

This is a constant background process for any dog