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Glucagon-like peptide-1 receptor agonist (GLP-1RA) and sodium-glucose cotransporter 2 inhibitor (SGLT2i) are currently recommended as first-line hypoglycaemic agents for patients with diabetes with established cardiovascular disease or multiple cardiovascular and renal risks [10]

However, CD-839 does not exert significant antitumor effects on pancreatic cancer cells, suggesting that monotherapy led to metabolic adaptation in cancer cells [185]