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In addition, steroids have well-documented side effects, including increasing the risk of infection, which already is substantial in patients with alcoholic hepatitis

After the membrane was blocked with 5% skim milk TBST (20 mM Tris-Cl (pH 7.4), 150 mM NaCl, 0.1% Tween-20), it was incubated with streptavidin (SA) coupled to horseradish peroxidase (HRP) (1:1000, Pierce) and washed three times with TBST for 10 min

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2.1.4 Dendritic cells: maturation, antigen presentation, and cytokine release Dendritic cells (DCs), as key antigen-presenting cells (APCs), orchestrate anti-tumor responses in the TIME ( Microbial metabolites like isodeoxycholic acid (isoDCA), converted from deoxycholic acid (DCA) by bacteria such as Eggerthella lenta and Clostridium scindens ( Similarly, secondary BAs like LCA and DCA suppress DC cytokine secretion (e.g., IL-12, IL-6) and co-stimulatory molecule expression through TGR5 activation, promoting tolerogenic phenotypes ( Nonetheless, BA effects vary by context

Rudolf JD, Alsup TA, Xu B, Li Z (2021) Bacterial terpenome