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The following information is based on dosages cited in preclinical animal studies and should be interpreted solely within that context

These effects explain why people on tirzepatide feel less hungry and eat significantly fewer calories without white-knuckling through constant cravings

The cytokines IL-1, IL-6, IL-13 and IL-22 have been demonstrated to alter intestinal transcription of CLDN2 [27,28,29,30], although the impact this has on subsequent pore pathway permeability has not been fully elucidated