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During the initial phase of treatment for pernicious anemia, serum potassium levels should be monitored to prevent hypokalemia and cardiac arrest

The McCoy 2013 paper extended this work by introducing N- and C-terminal modifications designed to enhance metabolic stability and hydrophobicity, ultimately producing Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) as an orally active, BBB-permeable analog [2]