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Van Der Heijde, D

Ginger extract exhibited the antioxidant effects in IL-1-mediated OS in human C28I2 chondrocyte cells by stimulating the expression of several AOEs, decreasing IL-1-induced ROS production, LPx, and by reducing apoptosis (Bax/Bcl-2 ratio, and caspase-3 activity) (130) ( Supplementary Table 1 )

The first isoenzyme is present in the mitochondria and is Mn 2+ dependent whereas another isoenzyme is available in the cytoplasm and is dependent on Cu