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6.2 Autophagy induction is an evolutionarily conserved function of the cGAS-STING signal Earlier studies have mainly focused on the mechanism of IFN induction by the cGAS-STING pathway

Within lysosomes, iron is normally reduced and recycled back to the cytoplasm via TRPML1 or DMT1 to meet metabolic demands ( 2+ levels and suppressing Fenton reactiondriven oxidative stress and ferroptosis