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Homocysteine levels are often elevated in people with MTHFR variants, especially the homozygous MTHFR C677T

Wiley et al., 2021)

These findings also underscore the antioxidant and anti-inflammatory properties of melatonin, highlighting the need for further research to elucidate optimal dosing strategies and long-term clinical outcomes

Although TREM2 could not be detected by the proteomics approach, ablation of p53 in adipocytes caused a significant decrease in mRNA expression of Trem2 in bulk eWAT and a trending reduction in sWAT, but not in BAT (Supplementary Fig

4.3 The GCH1-BH4 system Recent studies reveal that GCH1-mediated BH4 metabolism controls lipid peroxidation during erastin-induced ferroptosis