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However, peripheral distribution decreases the efficacy of oral therapy, requiring high doses, which causes potential systemic side effects (e.g., neutropenia)

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Findings also reveal that the liver function examination of a rat treated with cyclosporine exhibits significant changes in oxidative stress markers, a considerable rise in ALT, AST, and bilirubin levels in serum, mononuclear cell infiltration, and obvious mitochondrial damage (Korolczuk et al., 2016

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