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[DOI] [PubMed] [Google Scholar] 41.Agostinho P, Cunha RA, Oliveira C

A 2007 study conducted in Russia found that epithalon extended the lifespan of rats exposed to natural and constant illumination [9]

Aged mice (12 months, roughly equivalent to middle age in humans) administered MOTS-c for four weeks showed improved physical performance, grip strength, and metabolic markers compared to controls

Statistical analysis was performed by one-way analysis of variance (ANOVA) followed by Tukeys post hoc test using Minitab 16 and Students t-test

The CYP3A4 induction and inhibition assays also highlight the potential of iHLOs for dynamic pharmacological testing, a key aspect of drug safety evaluations 35