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Generally considered less efficacious than the psychostimulants (methylphenidate or amphetamines), and can produce unwanted sedative and hypotensive side effects for patients with ADHD

Historically, all these parameters were provided by oral mucosa biopsy

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Methods: Mouse models of advanced liver diseases were established by exposure to carbon tetrachloride (CCl 4 ) for 12 weeks, or high-fat, methionine-choline deficient diet (HFMCDD) for 16-20 weeks, mirroring human cHCV or MASLD pathology, respectively

Drug-metabolizing enzymes and efflux transporters in nasal epithelium: influence on the bioavailability of intranasally administered drugs