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When these complexes are saturated, excess free Fe 2+ accumulates in the labile iron pool (LIP), accelerating fenton reactions and increasing OH and L-O levels, thereby promoting lipid peroxidation and inducing ferroptosis

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Prolonged (48 h) pre-incubation with STW3-VI (40100 g/ml) was even more effective in reducing LPS-EB-induced TNF release by 25.064.8% (Figure 5C)