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Although described independently, these metabolic pathways are interconnected through mutual intermediates or crosstalk with metabolites or signaling pathway components, regulating T cell survival, proliferation, functional differentiation and metabolic reprogramming

In general, an increase in ADA magnitude correlated with loss of AMG 966 exposure on a per subject basis ( Figure 3A )

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Biological analyses were performed on PBMCs, assessing mitochondrial enzymology (citrate synthase and ETC complexes) and mitochondrial respiration using Seahorse XFe96 with the mitochondrial oxidative stress test