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those with low capacity will have Michaelis constants close to clinically relevant concentrations

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Reference Cutti, Rigon, Girelli, Angonese, Ulguim and Merotto2022)

Solomonov Y, Hadad N, Levy R (2018) The combined anti-inflammatory effect of astaxanthin, lyc-O-mato and carnosic acid in vitro and in vivo in a mouse model of peritonitis

The low-selenium condition in combination with three mycotoxins, deoxynivalenol (DON), nivalenol (NIV), and T-2, yielded pro-catabolic changes and hypertrophic phenotype of chondrocytes, as evidenced by the loss of aggrecan and type II collagen (COLII) and the increase in COLX and matrix metalloproteinases (MMPs) expression, respectively 71