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Bilateral lesions from 6-OHDA injections in the MFB produce dose-dependent, extensive retrograde degeneration of DA neurons in the SNc that can be quite severe leading to bradykinesia, changes in gait and nociception, cognitive deficits, depressive-like behavior, and enteric nervous system dysfunction [29]

Anatomical and physiological alterations of pregnancy

) 181213 (Iowa State University Press, 2000)