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NF-B signaling pathway can further contribute to inflammasome production by activating the transcription of inflammasome components, such as the NLRP3 and the pro forms of cytokines (IL-18, IL-1) (175)

Indeed, upon genetic ablation of the copper uptake transporter CTR1, a maneuver that lowers intracellular copper, autophagy is decreased in a mouse model of KRAS-driven lung cancer, paralleled by a sizeable reduction of tumorigenesis

This assay was successfully used to identify a large part of the currently approximately 80 known antisense oligonucleotide (ASO) binders and forms the basis of todays knowledge on ON drugprotein interactions 8 and how they modulate the pharmacological properties 9 of ON drugs

Gastaminza, G., Ruiz-Canela, M., Baiardini, I., Andrs-Lpez, B

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