glutathione conjugation as a bioactivation reaction

glutathione conjugation as a bioactivation reaction Xenobiotic metabolism Two-step metabolic activation to ortho-benzoquinone

Name: glutathione conjugation as a bioactivation reaction Xenobiotic metabolism Two-step metabolic activation to ortho-benzoquinone
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Two step metabolic activation to ortho benzoquinone intermediate and its role in 2,3,5,4 tetrahydroxystilbene 2 O D glucoside induced liver injury in mice Drug Metabolism and Disposition glutathione conjugates Glutathione Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation Conjugation of glutathione to a Phase II Drug Metabolism Full article: Bioactivation and reactivity research advances 2021 year in review Drug Metabolism Synthetic (Phase II) Reactions Springer Nature Link

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Description

Erythrocyte PLP shows a massive, transient increase within an hour after ingestion of pyridoxine (100 mg), and then decreases rapidly over the subsequent 4 hours (180)

The single dose, short (1 h) observation period, and lack of placebo arm are limitations in this proof-of-concept study and provide direction for follow-up studies