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In zinc deficient rats, kidney functions are compromised due to structural abnormalities, including reduced number of nephrons and renal fibrosis, and functional impairments, such as reduced glomerular filtration rate and proteinuria [458]

This scale enhances sample availability, allowing for frequent and substantial collection of conditioned media for multi omic analyses without perturbing the systems homeostasis, thereby furnishing a richer dataset for robust biomarker identification and pharmacokinetics/pharmacodynamics modeling

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Carafoli E (1991) Calcium pump of the plasma membrane