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PMID 8017933

In the available data, 5-Amino-1MQ has generally been reported as well-tolerated but generally well-tolerated in limited data is not the same as proven safe for everyone. Human safety data is still limited, long-term effects aren't fully characterized, and that uncertainty is itself a reason for medical oversight

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It should also be noted that not all of the listed products always contain B12, only those that have been specifically modified