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Carnosic acid, a naturally occurring antioxidant nutraceutical, decreases doxorubicin-induced cardiotoxicity by decreasing oxidative stress and its concomitant pathological consequences

However, a subgroup of patients may show overlapping problems involving undermethylation, low methylation reserve, oxidative stress and impaired mitochondrial resilience

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The anti-ferroptotic effect of TGF-1 via Bcl-2 might represent a compensatory survival mechanism in a subset of cells or under specific conditions

-Carotene increases protein expression of nuclear NRF2 and upregulates downstream targets containing antioxidant response elements (ARE) such as NADPH quinone oxidoreductase 1 (NQO1) and haeme oxygenase-1 (HO-1), thereby reducing oxidative damage to neurons 142