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D.ZiosiM.et al

HIF-1 is the key transcriptional factor that masterfully regulates endothelial cell biology and angiogenesis, particularly under hypoxic and oxidative stress conditions, by upregulating pro-angiogenic factors, such as VEGF 33

10.1023/a:1014890219513 Neurochem

So, its a good time to take a look at the facts

However, although numerous studies of DTP cells have extensively outlined the details of resistance mechanisms, many directions of research into the DTP cells in AML remain to be pursued