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Specific microbial shifts, such as an increase in Bacteroidetes ovatus following host AKR1D1 loss, can lead to the accumulation of isolithocholic acid (iso-LCA), which suppresses NK cell cytotoxicity and survival, potentially via TGR5 (119), are also enriched in colorectal cancer (CRC) and their derivatives, such as isoalloLCA ( However, the microbiota-BA axis can also generate signals conducive to anti-tumor immunity or complex immune regulation

34 GiacominiI.RagazziE.PasutG.MontopoliM

Shelbayeh OA, Arroum T, Morris S, Busch KB

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Nevertheless, particles within this size range are highly vulnerable to being cleared by alveolar macrophages, which can easily engulf particulates of micrometer size (Rodrigues et al., 2023)