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Discussion The structure of the ATRATRIPTOPBP1 AAD complex shows that TOPBP1 binds to ATR in three discontinuous segments

In animal model systems it has been shown that FOXO is involved in the regulation of long lifespan

362,515 Together, these findings indicate a regulatory effect of autophagy in protein homeostasis necessary for proper organ function, especially in the brain and other high energy-demanding organs

Its cognitive potential is inferred from TREK-1 knockout mouse phenotypes (enhanced memory) and from neurogenesis data rather than direct cognitive testing