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1 Introduction Proton ( 1 H) magnetic resonance spectroscopy (MRS) is a powerful tool for assessing the neurochemical profile of brain tissue and has been applied in vivo since the earliest days of MRI (Bottomley, 1997)

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Capitalizing the properties of Ru(II) complexes, researchers have designed a series of nanoruthenium complexes including, Ru(II)-selenium nanoparticles (Sun et al., 2013), Ru(II)-gold nanocomplexes (Rogers et al., 2014), Ru(II)-silicon nanocomplexes (Wang N