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GRX1-/- mice exhibit attenuated LPS-induced cytokine release (IL-1 and TNF-) and macrophage dysfunction, suggesting the dual role of GRX1 in the regulation of inflammation (90)

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Subsequent cell- and animal- based assays confirmed that Al 2 O 3 NPs caused mitochondria-dependent apoptosis and oxidative stress either in vitro or in vivo, which were consistent with the trends of gene regulation