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[4] A lack of sufficient thyroid hormones can also lead to nutrient deficiencies, as it makes nutrient extraction from food more difficult and less efficient

Sachs S, Bastidas-Ponce A, Tritschler S, et al

NNMT plays a key role in regulating cellular metabolism, NAD availability, and methylation pathways

Many providers offer B-12 shots based on symptoms and a brief assessment

Registered Phase 3 trials sponsored by Boehringer Ingelheim include obesity efficacy-and-safety studies, dedicated MASH/liver-outcome studies, and a large cardiovascular-safety study reflecting a strategy of testing survodutide across the metabolic-disease spectrum rather than in a single indication