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In a recent paper in Nature, Wang et al

doi:10.1007/s11010-008-9853-y Lee JM, Calkins MJ, Chan K, Kan YW, Johnson JA (2003) Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis

These reactions -- which are characterized by swelling, redness, itching, rashes, heat and pain -- are expected to last a day to a week

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In renal failure, MMA can climb to 300 to 700 nmol/L and stay elevated even after B12 treatment