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doi: 10.3390/ijms232415482 31 ChenDFZhangSXChenKEZhouBNWangPCosentinoLMet al

The T h 1 response is dominated by cell-mediated immunity, and delayed hypersensitivity (cytotoxic T cells) is initiated through macrophage production of IL-12 followed by production of interferon (IFN)- by T h 1 and natural killer cells