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(source) Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM

One large observational study linked low IGF-1 levels to higher body mass index (BMI) but couldnt prove cause and effect (15, 16, 17)

So we dont need to use any numbing or anesthesia during this treatment

Runx2/Osterix pathway: Upregulation of Runx2 (osteogenic differentiation core transcription factor) and Osterix expression induces directed differentiation of bone marrow mesenchymal stem cells into osteoblasts and increases new bone formation