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SARS-CoV-2 infection generates massive ROS production and the excessive oxidative damage is responsible for cytokine storm, undermined immunity, tissue damage and severe lung disease causing ARDS and death (Silvagno et al., 2020)

J., Quinlan, G

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Bone marrow mesenchymal stem cell-derived extracellular vesicles carrying circ_0050205 attenuate intervertebral disc degeneration

The authors postulate that therapeutic strategies aimed at modulating glutathione levels or transporter activity might mitigate disease progression in affected individuals