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Over time, factors like pollution, stress, UV exposure, and aging can deplete natural glutathione levels, leading to hyperpigmentation, dullness, and uneven skin tone

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(1995) The content of glutathione and glutathione S-transferases and the glutathione peroxidase activity in rat liver nuclei determined by a non-aqueous technique of cell fractionation

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OA is characterized by progressive loss of cartilage extracellular matrix (ECM) and pathological changes in other joint tissues such as subchondral bone sclerosis, osteophyte formation, and synovial inflammation 31