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TLC-2716 and TLC-6665 demonstrated comparable binding to and repression of LXR and LXR activity with half-maximal effective concentrations (EC 50 ) of 715 and 1417 nM, respectively (Fig

During viral RNA synthesis, notable structural rearrangements occur in this complex to accommodate the RNA 114

British Journal of Pharmacology 159: 122-128

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Moreover, following ACMG guidelines (Richards et al., 2015) a large proportion of variants can be classified as of uncertain significance (VUS) or benign, without considering their additive burden in shaping polygenic phenotypes