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As with other neurodegenerative diseases such as Alzheimers disease, Parkinsons disease, and Huntingtons disease, a significant number of fundamental studies have demonstrated that energy metabolism disorders resulting from mitochondrial dysfunction represent the primary pathophysiological phenotypes of amyotrophic lateral sclerosis (Sassani et al., 2020

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Peer review Peer review information Nature Reviews Endocrinology thanks Thomas Lutz and the other, anonymous, reviewer(s) for their contribution to the peer review of this work