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World J Microbiol Biotechnol 41 , 344 (2025)

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Nrf2 promotes -glutamyl-peptide (GC) synthesis and inhibits ferroptosis caused by Cys 2 deficiency by regulating the catalytic subunit of glutamate-cysteine ligase (GCLC) [89]

This occurs because the pituitary gland and adipose tissue are stimulated to produce androgens and luteinizing hormone, respectively, in response to increasing levels of androgens, which in turn heighten insulin resistance (IR) and hyperinsulinemia (Hg)