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Additionally, 1,25(OH)D promotes the expansion and functional enhancement of regulatory T cells (Tregs), not only by directly upregulating FoxP3 and the anti-inflammatory cytokine IL-10, but also by inducing a tolerogenic phenotype in dendritic cells, thereby indirectly facilitating Treg induction [168,169,170,171,172,173].Furthermore, 1,25(OH)D inhibits the mTORC1 pathway and activates fatty acid oxidation, creating a favorable metabolic milieu for Treg differentiationa combined epigeneticmetabolic regulatory mechanism that is emerging as a central feature of Vitamin Dmediated immunomodulation [174, 175]

Some individuals experience a sensation of warmth, flushing, or slight dizziness, especially if the infusion or injection is given rapidly

A case-control study of the relation between plasma selenium and asthma in European populations: a GAL2EN project

To, M., Simmonds, J., Alexander, C., 2017