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developed tolcapone-loaded PLGA nanosystem to reduce the hepatotoxic effect of entacapone while retaining its therapeutic efficacy in PD as illustrated in Fig

645,646,647 This leads to an inflammatory response, characterized by increased reactive oxygen species and cytokine activity, exacerbating liver damage

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[] Sarcopenia affects about one-third of patients with cirrhosis and up to 50% of patients with ALD or Child-Pugh class C cirrhosis, in addition, sarcopenia is independently associated with an ~2-fold higher risk of mortality in patients with cirrhosis

Sleep Apnea and the Risk of Incident Gout: A Population-Based, Body Mass Index-Matched Cohort Study