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10.1007/s13311-021-01130-6 Neurotherapeutics 204 ZhangL.ShimojiM.ThomasB.MooreD

10.1111/mmi.15151 72

B12 is generally safe when used under medical supervision

The liposomal form wraps it in phospholipid layers that protect it through the stomach so more of it actually reaches the bloodstream intact and gets to work

Additionally, physicochemical methods such as ultrasound-mediated reversible blood-brain barrier opening and magnetic nanoparticle-targeted delivery can transiently open the blood-brain barrier in a non-invasive manner