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Axon degeneration Several studies in humans and animals have demonstrated axon degeneration after long-term administration of chemotherapeutic agents, including the loss of large myelinated, small unmyelinated (more rarely), and intra-epidermal nerve fibers (IENF) which may be connected to the development of sensory-motoric peripheral neuropathy (Bradley et al., 1970

Unscheduled DNA synthesis, induced by the N -acetoxy-2-acetylamino- fluorene, was inhibited by ethylene oxide in human lymphocytes in vitro (Pero et al., 1981)

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The most important effect of cardiac cell necrosis is the development of cardiac arrhythmias due to the loss of functional contractile muscle mass and electrolyte imbalance caused by cell lysis [28]

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