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ALA pretreatment of breast cancer cell lines increases cell sensitivity to ionizing radiation and blocks transforming growth factor beta signaling inhibiting the migration and invasion of metastatic breast cancer cells [91]

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These findings in conjunction with the cytokine release observed in the whole blood assay ( Figure 7 ) indicate that the UCHT1-based CD3 binder may drive T cell activation in a target-independent manner, clinically manifesting in skin TRAEs

Both groups initially dropped to a significantly lower level after LPS administration, which lasted for 6 h, before returning to baseline at 9 h pi and remaining at this level until 14 d pi