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Interestingly, research has shown that even in animals lacking beta-3 adrenergic receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting additional metabolic pathways may be involved beyond the primary beta-3 receptor mechanism

As GSH represent the primary antioxidant defense system, the reduction of GSH could influence the redox homeostasis and elevate the naturally occurring ROS levels inside the cancer cells 40

Therefore, no definite advice on the amounts of vitamin E supplementation can be given for healthy individuals nor for patients with kidney disease, based on solid evidence from literature

The mice were fed normally after administration, and the survival status of the mice was observed, and the body weight and tumor volume of the mice were recorded as previously described