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This process is called the early phase reaction

In tumor cells, MTH1 acts as a protective factor against DNA damage, potentially to avert apoptosis induced by such damage, and may be upregulated in response

Funding This research was supported by the National Natural Science Foundation of China (32172727), the Sichuan Science and Technology Program (2024NSFSC0300 and 2024JDRC0072), and the National Undergraduate Training Program on Innovation and Entrepreneurship (202410626033 and 202510626056)

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Cigarette smoke induces proinflammatory cytokine release by activation of NF-B and posttranslational modifications of histone deacetylase in macrophages