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As such, the presence of BMAL1 in the nuclei is not solely indicative of Nrf2 transcription nor the presence of NRF2 in the nuclei solely indicative of transcription of genes involved in GSH homeostasis

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Higher (10 g/kg) dosage was effective either after a single or daily regimen, whereas lower (10 ng/kg) dosage, previously ineffective given as a single application, becomes efficacious when applied as a daily regimen