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HHCY in HF could also be a consequence of kidney dysfunction associated with HF [207] since this organ is responsible for homocysteine clearance

For heart patients, it is important to consider the heart pumping (LVEF), and usually it should be given to patients with poor heart function under 30% LVEF, except few cases when it is really important

These considerations are particularly important in research settings where compound consistency, stability assessment, and reproducibility are critical experimental factors.