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The research teams who are authors on this manuscript have been working closely together for over 7 years, and research roles, responsibility and authorship topics are clearly discussed early in research planning, and we strive to be as inclusive as possible, to attribute credit where it is due

BPC-157 (Body Protection Compound-157, sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) is a 15-amino-acid peptide isolated from gastric juice

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In IBD, chronic inflammation disrupts this stabilitypathogenic bacteria (e.g., Ruminococcus gnavus ) proliferate rapidly, while beneficial taxa (e.g., Faecalibacterium prausnitzii ) decline, leading to chaotic microbial fluctuations and reduced diversity ( Lactobacillus rhamnosus GG (LGG, 10 9 CFU/day) markedly improved microbiota diversity, reversing dysbiosis by enriching beneficial taxa such as Bifidobacterium, Olsenella, Paenibacillus , and butyrate-producing bacteria ( Zhiphyllobacterium, Osteobacillus , and Desulphurobacteria , thereby alleviating colonic inflammation in UC mouse models ( Under physiological conditions, the mucus layer segregates luminal bacteria from intestinal epithelial cells (IECs), and the immune system maintains tolerance toward luminal antigens ( Metabolic studies further link microbial composition to functional pathways

[DOI] [PubMed] [Google Scholar] Zhao J, Taverne MA, van der Weijden GC, Bevers MM, van den Hurk R