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The ISC is one of the evolutionarily oldest prosthetic groups most commonly facilitating an electron transfer process in support of a complex redox biology

mitochondrial-targeted delivery of polyphenol-mediated antioxidases complexes against Pyroptosis and Inflammatory diseases

However, researchers point out that some may be more sensitive to induction or ingest more kavalactones than acceptable for daily intakes, and that increased 1A1 expression may partly contribute to kava-induced hepatotoxicity

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