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Diselenolane-mediated cellular uptake: efficient cytosolic delivery of probes, peptides, proteins, artificial metalloenzymes and protein-coated quantum dots

Following this, BH4 can be recycled back from its oxidized form, dihydrobiopterin, with the help of dihydrofolate reductase using NAD(P)H (182,183)

3.2 Role of TGF- in radiation skin fibrosis TGF- is a cytokine intricately involved in the fibrotic process across various organs and tissues ( 3.2.1 TGF- Signaling and cellular mechanisms in radiation-induced fibrosis TGF- exerts its effects through the activation and proliferation of fibroblasts, leading to ECM accumulation ( TGF- expression is dose-dependent on radiation exposure, binding to its receptors to form a trimeric complex which can lead to tissue fibrosis ( Figure 2 )

This recycling process enhances the overall antioxidant capacity of the body

(PubMed) Yuan J, Yu Y, Zhu T, Lin X, Jing X, Zhang J